vascular endothelial cells การใช้

• Delivery into adult vascular endothelial cells stressed during balloon angioplasty ).
• The primary target appears to be the vascular endothelial cell.
• Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries.
• Tyrosine kinase receptors are typically expressed on vascular endothelial cells and specific macrophages for immune responses.
• PLAT is secreted by vascular endothelial cells and acts as a serine protease that converts plasminogen to plasmin.
• Simultaneously, precursors of vascular endothelial cells begin to take their position at the tips of the renal tubules.
• Specifically, NO has been shown to play an important negative feedback regulatory role on NOS3, and therefore vascular endothelial cell function.
• Interactions of IL-4 with TNF? promote structural changes to vascular endothelial cells, thus playing an important role in tissue inflammation.
• In vascular endothelial cells the binding of S1P to S1PR1 induces migration, proliferation, cell survival and morphogenesis into capillary-like structures.
• Vascular endothelial cells also express TLR4 and MD-2 and so respond to LPS directly, as well as via cytokines and nitric oxide.
• Specifically, Sulf1 inhibited the ability of vascular endothelial cell heparan sulfate to participate in complex formation with FGF-2, thereby abolishing growth signaling.
• Accordingly, MCAM is highly expressed by cells that are components of the blood vessel wall, including vascular endothelial cells, smooth muscle cells and pericytes.
• This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
• It has also been found that ectopic expression of " Prox1 " in blood vascular epithelium can force vascular endothelial cells to convert into lymphatic cells.
• It should be noted that vascular endothelial cells and associated pericytes are often abnormal in tumors and that the blood brain barrier may not always be intact in brain tumors.
• Up-regulation of glyceraldehyde-3-phosphate dehydrogenase expression is maximal ( 4-5 fold ) following hypoxic conditions of ~ 24 hours in vascular endothelial cells.
• Finally, AGEs can bind to RAGE ( receptor for advanced glycation end products ) and cause oxidative stress as well as activation of inflammatory pathways in vascular endothelial cells.
• The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.
• VEGF-A shows prominent activity with vascular endothelial cells, primarily through its interactions with the VEGFR1 and-R2 receptors found in prominently on the endothelial cell membrane.
• The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome.